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KIT amplification and gene mutations in acral/mucosal melanoma in Korea

โœ Scribed by JINA YUN; JEEYUN LEE; JIRYEON JANG; EUI JIN LEE; KEE TAEK JANG; JUNG HAN KIM; KYOUNG-MEE KIM


Book ID
109344176
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
77 KB
Volume
119
Category
Article
ISSN
0365-5555

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Pathological activation of KIT in metast
โœ Atsuko Ashida; Minoru Takata; Hiroshi Murata; Kenji Kido; Toshiaki Saida ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 255 KB

## Abstract Recent studies showed __KIT__ gene aberrations in a substantial number of melanomas on acral skin and mucosa, suggesting the therapeutic benefit of tyrosine kinase inhibitors, such as imatinib. We therefore examined the expression and mutations of __KIT__ in 4 primary and 24 metastatic