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C-kit Expression in Canine Mucosal Melanomas

✍ Scribed by Newman, S. J.; Jankovsky, J. M.; Rohrbach, B. W.; LeBlanc, A. K.

Book ID: 115503884
Publisher: American College of Veterinary Pathologists
Year: 2011
Tongue: English
Weight: 478 KB
Volume: 49
Category: Article
ISSN: 0300-9858
DOI: 10.1177/0300985811414032

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## Abstract Recent studies showed __KIT__ gene aberrations in a substantial number of melanomas on acral skin and mucosa, suggesting the therapeutic benefit of tyrosine kinase inhibitors, such as imatinib. We therefore examined the expression and mutations of __KIT__ in 4 primary and 24 metastatic