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Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

✍ Scribed by Shin-ichiro Ikebe; Masashi Tanaka; Kinji Ohno; Wataru Sato; Kazuki Hattori; Tomoyoshi Kondo; Yoshikuni Mizuno; Takayuki Ozawa

Book ID
115762752
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
614 KB
Volume
170
Category
Article
ISSN
0006-291X

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## Abstract The reduced form of nicotinamide adenine dinucleotide coenzyme Q reductase (complex I) activity has recently been shown to be deficient in the substantia nigra of patients dying with Parkinson's disease. This biochemical defect is identical to that produced by the neurotoxin 1‐methyl‐4‐