Mitochondrial DNA polymorphisms and the risk of Parkinson’s disease in Taiwan
✍ Scribed by C. M. Chen; C. C. Kuan; G.-J. Lee-Chen; Y. R. Wu
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 69 KB
- Volume
- 114
- Category
- Article
- ISSN
- 1435-1463
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## Abstract The reduced form of nicotinamide adenine dinucleotide coenzyme Q reductase (complex I) activity has recently been shown to be deficient in the substantia nigra of patients dying with Parkinson's disease. This biochemical defect is identical to that produced by the neurotoxin 1‐methyl‐4‐
The mitochondrial DNA (mtDNA) sequence was determined on 3 patients with Alzheimer's disease (AD) exhibiting AD plus Parkinson's disease (PD) neuropathologic changes and one patient with PD. Patient mtDNA sequences were compared to the standard Cambridge sequence to identify base changes. In the fir
## Abstract Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we