Inclusion complex of fenbufen with β-cyclodextrin
✍ Scribed by I. Bratu; J. M. Gavira-Vallejo; A. Hernanz; M. Bogdan; Gh. Bora
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2004
- Tongue
- English
- Weight
- 108 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Abstract
An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by ^1^H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (M^−1^) was calculated. The geometry of the inclusion complex was established based on MM+ molecular mechanics calculations. © 2004 Wiley Periodicals, Inc. Biopolymers, 2004
📜 SIMILAR VOLUMES
AM1 semiempirical molecular orbital calculations have been performed Ž . on the inclusion complexes of -cyclodextrin -CD with methylated benzoic acids in two orientations, the ''head-first'' and ''tail-first'' positions. In the former, the CO H 2 group points toward the primary hydroxyls of the CD
## Abstract ^1^H‐NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (α‐ or γ‐cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if γ‐cyclodextrin is used, whereas in the case of α‐cyclodextrin no inclusion complex was obtained. The stoichiometry of th