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Availability of NSAIDH β-Cyclodextrin Inclusion Complexes

✍ Scribed by Isabella Orienti; Cristina Cavallari; Vittorio Zecchi; Adamo Fini


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
343 KB
Volume
322
Category
Article
ISSN
0365-6233

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Inclusion complex of fenbufen with β-cyc
✍ I. Bratu; J. M. Gavira-Vallejo; A. Hernanz; M. Bogdan; Gh. Bora 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 108 KB 👁 1 views

## Abstract An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by ^1^H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (__M__^−1^) was calculated. The geometry of the inclusion complex was established

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AM1 semiempirical molecular orbital calculations have been performed Ž . on the inclusion complexes of ␤-cyclodextrin ␤-CD with methylated benzoic acids in two orientations, the ''head-first'' and ''tail-first'' positions. In the former, the CO H 2 group points toward the primary hydroxyls of the CD