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1H-NMR study of the inclusion processes for α- and γ-cyclodextrin with fenbufen

✍ Scribed by I. Bratu; J. M. Gavira-Vallejo; A. Hernanz

Publisher
Wiley (John Wiley & Sons)
Year
2005
Tongue
English
Weight
272 KB
Volume
77
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

^1^H‐NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (α‐ or γ‐cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if γ‐cyclodextrin is used, whereas in the case of α‐cyclodextrin no inclusion complex was obtained. The stoichiometry of the fenbufen/γ‐cyclodextrin complex is of the [2:1] type. The geometry of this supramolecular architecture was established through MM+ molecular mechanics calculations. © 2005 Wiley Periodicals, Inc. Biopolymers 77: 361–367, 2005

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