Complexation of Hydrocortison with β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin
✍ Scribed by Andrea Preiss; Wolfgang Mehnert; Karl-Heinz Frömming
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 451 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0365-6233
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## Abstract An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by ^1^H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (__M__^−1^) was calculated. The geometry of the inclusion complex was established
## Abstract Spectroscopic and molecular modeling techniques have been employed to study the interaction of the oxicam group of nonsteroidal antiinflammatory drugs (NSAIDs) with a polysaccharide such as β‐cyclodextrin (β‐cd). β‐cd is a good drug delivery system and is known to reduce harmful side ef