✦ LIBER ✦

Incidence and significance of hepatitis B core antibody in a healthy blood donor population

✍ Scribed by A. D. Kitchen; T. J. Harrison; T. J. Meacock; A. J. Zuckerman; J. F. Harrison

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 441 KB
Volume: 25
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890250110

No coin nor oath required. For personal study only.

✦ Synopsis

To determine the current incidence of hepatitis B core antibody (anti-HBc) in a healthy blood donor population, 1,893 donors were screened for anti-HBc. Forty-one (2.16%) were found to be initially positive and 35 (1.85%) repeatably positive. Sera from the repeatably positive donors were further screened for hepatitis B surface antibody (anti-HBs), and hepatitis B virus DNA (HBV DNA) by dot hybridisation. The repeatably positive donors were subsequently recalled for further investigation, and their peripheral blood lymphocytes were also screened for HBV DNA by dot hybridisation. Eighteen (51.4%) of the anti-HBc-positive donors were also anti-HBs-positive. HBV DNA was not detected in the serum or the lymphocytes of any of the anti-HBc-positive donors.

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