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Significance of isolated hepatitis B core antibodies detected by enzyme immunoassay in a high risk population

✍ Scribed by Dr. A. C. M. Kroes; W. G. V. Quint; R. A. Heijtink

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
454 KB
Volume
35
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Serum samples, which were found positive for anti‐HBc and negative for HBsAg and anti‐HBs during routine testing with Abbott enzyme immunoassays (EIA), were collected prospectively. The samples were obtained from patients with a high risk of hepatitis B. Further analysis was carried out using radioimmunoassays and tests for additional markers of hepatitis B. 84 of the 203 initially collected samples (41.4%) were found positive for anti‐HBs by RIA. Of the 119 samples negative for anti‐HBs by RIA, 103 were available for further investigation, and 35 (34.0%) of these were negative for anti‐HBc by RIA. This indicates that low sensitivity of the anti‐HBs EIA and non‐specificity of the anti‐HBc EIA may account for about 60% of the cases presenting with isolated anti‐HBc at initial testing. Fifty‐two samples positive for anti‐HBc by RIA, with isolated anti‐HBc confirmed after RIA testing for HBsAg and anti‐HBs, were examined further: anti‐HBe was detected in 16 sera, anti‐ HDV in one serum and HBV‐DNA in 5 sera by PCR. Additional testing of serum samples with isolated anti‐HBc is warranted.

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