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Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy

✍ Scribed by S. K. Panda; M. K. Bhan; D. K. Guha; A. Gupta; R. Datta; A. J. Zuckerman; Dr. N. C. Nayak

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 392 KB
Volume: 24
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890240311

No coin nor oath required. For personal study only.

✦ Synopsis

The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.

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