Epigenetic inactivation of SOCS-1 by CpG
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Yasuhiro Oshimo; Kazuya Kuraoka; Hirofumi Nakayama; Yasuhiko Kitadai; Kazuhiro Y
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Article
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2004
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John Wiley and Sons
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French
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## Abstract __Suppressor of cytokine signaling (SOCS)โ1__ inhibits signaling of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway by several cytokines and has tumor suppressor activity. Methylation of the __SOCSโ1__ CpG island has been shown to inactivate the