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Hypermethylation of the 5′CpG island of the FHIT gene in clear cell renal carcinomas

✍ Scribed by Sergiy Kvasha; Vasily Gordiyuk; Alexandr Kondratov; Dmytro Ugryn; Yury M. Zgonnyk; Alla V. Rynditch; Alexandr F. Vozianov

Book ID
115544965
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
484 KB
Volume
265
Category
Article
ISSN
0304-3835

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Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor loc