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Inactivation of the FHIT gene in clear cell renal carcinomas

✍ Scribed by S. Kvasha; V. Gordiyuk; A. Kondratov; D. Ugryn; A. Rynditch

Book ID
119598975
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
90 KB
Volume
6
Category
Article
ISSN
1359-6349

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✍ Peter Bugert; MΓ³nica Wilhelm; Gyula Kovacs πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 167 KB

The FHIT gene locus at 3p14.2 covers about 500 kb, including the fragile site FRA3B and the constitutional t(3;8) breakpoint associated with the development of multiple renal cell carcinomas (RCC). A terminal deletion of the short arm of chromosome 3 with the most distal breakpoint in the FRA3B regi