In vivo31P nuclear magnetic resonance (NMR) study of cerebral metabolism during histotoxic hypoxia in mice
β Scribed by Michel Peres; Philippe Meric; Bertrand Barrere; Corinne Pasquier; Guy Beranger; Jean -Claude Beloeil; Jean -Yves Lallemand; Jacques Seylaz
- Book ID
- 112457727
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 708 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0885-7490
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Twenty minutes of hypoxic hypoxia in five anesthetized rats reversibly reduced cerebral PCr and pH while ATP stayed constant. Complete metabolic and neurologic recovery occurred after oxygen was restored. Careful control of physiological parameters resulted in metabolite changes that were the same,
## Abstract Energy metabolites in rat brain under the same level of hypoxia were monitored by ^31^P NMR in both horizontal and vertical magnets. The changes in PCr, P|, and pHI in the vertical setting toward the end of hypoxia were significantly larger and the recovery in the horizontally held anim