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An in vivo31P NMR study of cerebral hypoxic hypoxia in rats

✍ Scribed by Lawrence Litt; Ricardo González-Méndez; Philip R. Weinstein; John W. Severinghaus; William K. Hamilton; Julia Shuleshko; Joseph Murphy-Boesch; Thomas L. James

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
457 KB
Volume
3
Category
Article
ISSN
0740-3194

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✦ Synopsis

Twenty minutes of hypoxic hypoxia in five anesthetized rats reversibly reduced cerebral PCr and pH while ATP stayed constant. Complete metabolic and neurologic recovery occurred after oxygen was restored. Careful control of physiological parameters resulted in metabolite changes that were the same, within errors, in each animal.

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