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In vivo studies on chemically induced aneuploidy in mouse somatic and germinal cells

โœ Scribed by Paola Leopardi; Andrea Zijno; Bruno Bassani; Francesca Pacchierotti


Book ID
113194375
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
941 KB
Volume
287
Category
Article
ISSN
0027-5107

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The genotoxicity of rifampicin was tested for sister chromatic exchange in bone marrow cells and for structural chromosomal aberrations in mouse germ cells. Sister chromatid exchange frequency increased after 160, 240 and 310 mg kg-' body wt. doses but not after 80 mg kg-'. In spermatocytes, 80 mg