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Cytogenetic effects of rifampicin in somatic and germinal cells of the mouse

✍ Scribed by E. I. Aboul-Ela

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
156 KB
Volume
15
Category
Article
ISSN
0260-437X

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✦ Synopsis

The genotoxicity of rifampicin was tested for sister chromatic exchange in bone marrow cells and for structural chromosomal aberrations in mouse germ cells.

Sister chromatid exchange frequency increased after 160, 240 and 310 mg kg-' body wt. doses but not after 80 mg kg-'. In spermatocytes, 80 mg kg-' rifampicin increased the frequency of chromosomal aberrations from the 3.5% control level to 14% after 1 day and 34.5% after 7 days.

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