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In vivo MRS measurement of deoxymyoglobin in human forearms

✍ Scribed by Zhiyue Wang; Elizabeth A. Noyszewski; John S. Leigh Jr.

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 327 KB
Volume: 14
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910140314

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In vivo MRS measurement of deoxymyoglobin (deoxy‐Mb) in human forearms was performed by observing the N‐δ proton of F8 proximal histidine. The concentration of deoxy‐Mb reflects the oxygen level in the muscle. In resting muscles, the deoxy‐Mb level was below the detection sensitivity. When ischemia was introduced by arterial occlusion, the time‐resolved NMR spectra (with 1 min resolution) was recorded to follow the change in the deoxy‐Mb signal. The result shows that deoxy‐Mb signal builds up and levels off within 6 min. This technique may be used to study bioenergetics of muscle during exercise and under pathological conditions. © 1990 Academic Press, Inc.

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