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Sensitivity of in vivo mrs of the n-δ proton in proximal histidine of deoxymyoglobin

✍ Scribed by Zhiyue Wang; Dah-Jyuu Wang; Elizabeth A. Noyszewski; Andrew R. Bogdan; John C. Haselgrove; Ravinder Reddy; Robert A. Zimmerman; John S. Leigh

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
330 KB
Volume
27
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The sensitivity of in vivo MRS of the N‐δ proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T~1~ of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of^31^P MRS of PCr in normal resting muscles are compared.

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