In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs
โ Scribed by Satyanarayana Valiveti; Dana C. Hammell; Kalpana S. Paudel; Mohamed O. Hamad; Peter A. Crooks; Audra L. Stinchcomb
- Book ID
- 113690753
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 339 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0168-3659
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The purpose of this study was to compare the percutaneous absorption and bioconversion of naltrexone (NTX), naltrexone-3-O-valerate (VAL), and naltrexone-3-O-(2 0 -ethylbutyrate) (ETBUT) in a human skin equivalent model (EpiDerm TM ) and in fresh human skin in vitro. NTX diffusion and metabolism to
The aim of the present study was to evaluate the transdermal delivery of 6-b-naltrexol (NTXOL), the active metabolite of naltrexone (NTX), across human skin and guinea pig skin in vitro and in hairless guinea pigs in vivo. NTXOL may be responsible for much of NTX's pharmacologic activity. In vitro d