In Vitro/in VivoCorrelation of Transdermal Naltrexone Prodrugs in Hairless Guinea Pigs
โ Scribed by Satyanarayana Valiveti; Kalpana S. Paudel; Dana C. Hammell; Mohamed O. Hamad; Jianhong Chen; Peter A. Crooks; Audra L. Stinchcomb
- Book ID
- 106492577
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 594 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0724-8741
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The aim of the present study was to evaluate the transdermal delivery of 6-b-naltrexol (NTXOL), the active metabolite of naltrexone (NTX), across human skin and guinea pig skin in vitro and in hairless guinea pigs in vivo. NTXOL may be responsible for much of NTX's pharmacologic activity. In vitro d
Controlled-release delivery of 6-beta-naltrexol (NTXOL), the major active metabolite of naltrexone, via a transdermal patch is desirable for treatment of alcoholism. Unfortunately, NTXOL does not diffuse across skin at a therapeutic rate. Therefore, the focus of this study was to evaluate microneedl