In vivo evaluation of a transdermal codrug of 6-β-naltrexol linked to hydroxybupropion in hairless guinea pigs
✍ Scribed by Paul K. Kiptoo; Kalpana S. Paudel; Dana C. Hammell; Mohamed O. Hamad; Peter A. Crooks; Audra L. Stinchcomb
- Book ID
- 113591924
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 531 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0928-0987
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Controlled-release delivery of 6-beta-naltrexol (NTXOL), the major active metabolite of naltrexone, via a transdermal patch is desirable for treatment of alcoholism. Unfortunately, NTXOL does not diffuse across skin at a therapeutic rate. Therefore, the focus of this study was to evaluate microneedl
The aim of the present study was to evaluate the transdermal delivery of 6-b-naltrexol (NTXOL), the active metabolite of naltrexone (NTX), across human skin and guinea pig skin in vitro and in hairless guinea pigs in vivo. NTXOL may be responsible for much of NTX's pharmacologic activity. In vitro d