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Enhancement of transdermal delivery of 6-β-naltrexol via a codrug linked to hydroxybupropion

✍ Scribed by Paul K. Kiptoo; Mohamed O. Hamad; Peter A. Crooks; Audra L. Stinchcomb


Book ID
113691227
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
193 KB
Volume
113
Category
Article
ISSN
0168-3659

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The aim of the present study was to evaluate the transdermal delivery of 6-b-naltrexol (NTXOL), the active metabolite of naltrexone (NTX), across human skin and guinea pig skin in vitro and in hairless guinea pigs in vivo. NTXOL may be responsible for much of NTX's pharmacologic activity. In vitro d