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In vivo evaluation of 2′-deoxy-2′-[18F]fluoro-5-iodo-1-β-D-arabinofuranosyluracil ([18F]FIAU) and 2′-deoxy-2′-[18F]fluoro-5-ethyl-1-β-D-arabinofuranosyluracil ([18F]FEAU) as markers for suicide gene expression

✍ Scribed by Mian M. Alauddin; Antranic Shahinian; Ryan Park; Michel Tohme; John D. Fissekis; Peter S. Conti


Publisher
Springer
Year
2007
Tongue
English
Weight
233 KB
Volume
34
Category
Article
ISSN
0340-6997

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📜 SIMILAR VOLUMES


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## Abstract Synthesis of 2′‐deoxy‐2′‐[^18^F]fluoro‐5‐methyl‐1‐__β__‐D‐arabinofuranosyluracil ([^18^F]‐FMAU) is reported. 2‐Deoxy‐2‐[^18^F]fluoro‐1,3,5‐tri‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** was prepared by the reaction of the respective triflate **1** with tetrabutylammonium[^18^F]fluoride. Th

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## Abstract Several 2′‐deoxy‐2′‐[^18^F]fluoro‐1‐__β__‐D‐arabinofuranosyluracil derivatives have been synthesized. Coupling of 1‐bromo‐2‐deoxy‐2‐[^18^F]fluoro‐3,5‐di‐O‐benzoyl‐__α__‐D‐arabinofuranose **2** with protected uracil derivatives **3a–e** followed by hydrolysis and high‐performance liquid

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## Abstract We have synthesized __β__‐O‐D‐galactopyranosyl‐(1,4′)‐2′‐[^18^F]fluoro‐2′‐deoxy‐D‐glucopyranose (2′‐[^18^F]fluorodeoxylactose, ^18^FDL) using an enzymatic method starting from ^18^FDG in order to evaluate this compound with regard to its usefulness for __in vivo__ visualization of the e