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In vivo 1H spectroscopy of the human brain following electroconvulsive therapy

✍ Scribed by Dr Bryan T. Woods; Tak-Ming Chiu

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
522 KB
Volume
28
Category
Article
ISSN
0364-5134

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✦ Synopsis

Recent advances in the methodology of magnetic resonance spectroscopy now permit localized proton ('H) spectroscopy of the human brain in clinicd magnetic resonance systems. In this study, localized 'H spectroscopy was used to observe directly the stimulation of brain metabolic activity in patients undergoing electroconvulsive therapy (ECT) and to compare results obtained before and after treatments. Persistent increases in lactate were expected on the basis of animal data but these increases were small and equivocal 1 hour after ECT. In contrast, a large increase in a lipid signal from before to after ECT was observed in 5 patients when short echo times were used. We postulate that a significant portion of this lipid signal is related to maximal activation of the phosphatidylinositol second messenger system by single seizures, and that the sustained postictal effects of activation of the phosphatidylinositol system (increased levels of diacylglycerol and free fatty acids) have generalized inhibitory effects potentially relevant to both the clinical pathophysiology of seizures and the efficacy of ECT in major affective disorders.

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