In vivo 1H NMR spectroscopy of the human brain at 7 T

✍ Scribed by Ivan Tkáč; Peter Andersen; Gregor Adriany; Hellmut Merkle; Kâmil Uǧurbil; Rolf Gruetter

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 187 KB
• Volume: 46
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1213

✦ Synopsis

Abstract

In vivo ^1^H NMR spectra from the human brain were measured at 7 T. Ultrashort echo‐time STEAM was used to minimize J‐modulation and signal attenuation caused by the shorter T~2~ of metabolites. Precise adjustment of higher‐order shims, which was achieved with FASTMAP, was crucial to benefit from this high magnetic field. Sensitivity improvements were evident from single‐shot spectra and from the direct detection of glucose at 5.23 ppm in 8‐ml volumes. The linewidth of the creatine methyl resonance was at best 9 Hz. In spite of the increased linewidth of singlet resonances at 7 T, the ability to resolve overlapping multiplets of J‐coupled spin systems, such as glutamine and glutamate, was substantially increased. Characteristic spectral patterns of metabolites, e.g., myo‐inositol and taurine, were discernible in the in vivo spectra, which facilitated an unambiguous signal assignment. Magn Reson Med 46:451–456, 2001. © 2001 Wiley‐Liss, Inc.