In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience

✍ Scribed by Hao Lei; Xiao-Hong Zhu; Xiao-Liang Zhang; Kamil Ugurbil; Wei Chen

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 385 KB
• Volume: 49
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.10379

✦ Synopsis

Abstract

In vivo ^31^P spectra were acquired from the human primary visual cortex at 7 T. The relaxation times of the cerebral metabolites, intracellular pH, rate constant (k~f~) of the creatine kinase (CK) reaction, and nuclear Overhauser enhancement (NOE) on the detected phosphorus moieties from irradiation of the water spins were measured from normal subjects. With a 5‐cm‐diameter surface coil, 3D ^31^P chemical shift imaging was performed with a spatial resolution of 7.5 ml and an acquisition resolution of 8 min, resulting in a signal‐to‐noise ratio (SNR) for phosphocreatine (PCr) resonance of 32. The apparent T~1~ and T~2~ of PCr measured at 7 T were 3.37 ± 0.29 s and 132.0 ± 12.8 ms, respectively, which were considerably longer than those of adenosine triphosphate (ATP) (T~1~: 1.02–1.27 s; T~2~: 25–26 ms). The NOE measured in this study was 24.3% ± 1.6% for PCr, and 10% for ATP. The k~f~ measured in the human primary visual cortex was 0.24 ± 0.03 s^−1^. The results from this study suggest that ultra‐high‐field strength is advantageous for performing in vivo ^31^P magnetic resonance spectroscopy (MRS) in the human brain. Magn Reson Med 49:199–205, 2003. © 2003 Wiley‐Liss, Inc.