We have used in vivo 19F NMR spectroscopy to study the metabolism of 5-fluorouracil (FUra) in tumors with and without pretreatment with methotrexate (MTX). Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha-fluoro-beta-alanine (F beta ALA), alpha-fluoro-be
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues: An assessment of drug metabolism
β Scribed by Malcolm J.W. Prior; Ross J. Maxwell; John R. Griffiths
- Book ID
- 115781485
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 749 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0006-2952
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In vivo 19F nuclear magnetic resonance (NMR) spectroscopy has the potential to non-invasively measure the concentration of 5-fluorouracil (FUra) and some of its metabolites in humans. Such a measure could be useful in predicting and optimizing the response of individual patients treated with FUra. T
## Abstract A uridine phosphorylase inhibitor, 5βbenzylacyclouridine (BAU), has been utilized as biochemical modulator of 5βfluorouracil (5βFU) antiβtumor activity in a murine tumor model. The effect of BAU on 5βFU metabolism has been evaluated using __in vitro__ and __in vivo__ ^19^F NMR spectrosc