✦ LIBER ✦

A Non-invasive Study of Drug Metabolism in Patients as Studied by 19F NMR Spectroscopy of 5-Fluorouracil

✍ Scribed by WALTER WOLF; MICHAEL S. SILVER; MICHAEL J. ALBRIGHT; HORST WEBER; ULRICH REICHARDT; ROLF SAUER

Book ID: 119859735
Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 120 KB
Volume: 508
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.1987.tb32946.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Non-invasive 19F-NMRS of 5-fluorouracil

Non-invasive 19F-NMRS of 5-fluorouracil in pharmacokinetics and pharmacodynamic studies

✍ W. Wolf; V. Waluch; C. A. Presant 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 2 views

Knowledge of the exact dose and rate at which an antitumor agent is delivered to its target site is postulated to be crucial to proper patient management. It is now possible to obtain such information using noninvasive 19 F-NMRS (nuclear magnetic resonance spectroscopy) following the administration

In vivo monitoring of changes in 5-fluor

In vivo monitoring of changes in 5-fluorouracil metabolism induced by methotrexate measured by 19F NMR spectroscopy

✍ Jason A. Koutcher; Robert C. Sawyer; Alice B. Kornblith; Robert L. Stolfi; Danie 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 711 KB

We have used in vivo 19F NMR spectroscopy to study the metabolism of 5-fluorouracil (FUra) in tumors with and without pretreatment with methotrexate (MTX). Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha-fluoro-beta-alanine (F beta ALA), alpha-fluoro-be

In vivo 19F NMR spectroscopy of the anti

In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues: An assessment of drug metabolism

✍ Malcolm J.W. Prior; Ross J. Maxwell; John R. Griffiths 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 749 KB

Evidence of a new metabolic pathway of 5

Evidence of a new metabolic pathway of 5-fluorouracil in Escherichia coli from in vivo 19F-NMR spectroscopy

✍ Kuan Rong Lee; Shih Yi Sheu 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 665 KB

Fluorine-19 NMR spectroscopic studies of

Fluorine-19 NMR spectroscopic studies of the metabolism of 5-fluorouracil in the liver of patients undergoing chemotherapy

✍ Walter Wolf; Michael J. Albright; Michael S. Silver; Horst Weber; Ulrich Reichar 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 495 KB

Fluorine-19 nuclear magnetic resonance allows direct observation of fluorinated drugs and their metabolites in the human body without background signal from the tissue. A well-known fluorinated chemotherapeutic drug, 5-fluorouracil, and its metabolites were observed noninvasively in the liver of thr

1H NMR as a non-invasive method of study

1H NMR as a non-invasive method of studying metabolism in vivo

✍ S.R. Williams; D.G. Gadian; E. Proctor 📂 Article 📅 1988 🏛 Elsevier Science ⚖ 79 KB