Evidence of a new metabolic pathway of 5-fluorouracil in Escherichia coli from in vivo 19F-NMR spectroscopy
β Scribed by Kuan Rong Lee; Shih Yi Sheu
- Book ID
- 119120908
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 665 KB
- Volume
- 1011
- Category
- Article
- ISSN
- 0167-4889
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In vivo 19F nuclear magnetic resonance (NMR) spectroscopy has the potential to non-invasively measure the concentration of 5-fluorouracil (FUra) and some of its metabolites in humans. Such a measure could be useful in predicting and optimizing the response of individual patients treated with FUra. T
## Abstract A uridine phosphorylase inhibitor, 5βbenzylacyclouridine (BAU), has been utilized as biochemical modulator of 5βfluorouracil (5βFU) antiβtumor activity in a murine tumor model. The effect of BAU on 5βFU metabolism has been evaluated using __in vitro__ and __in vivo__ ^19^F NMR spectrosc