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Evidence of a new metabolic pathway of 5-fluorouracil in Escherichia coli from in vivo 19F-NMR spectroscopy

✍ Scribed by Kuan Rong Lee; Shih Yi Sheu


Book ID
119120908
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
665 KB
Volume
1011
Category
Article
ISSN
0167-4889

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## Abstract A uridine phosphorylase inhibitor, 5‐benzylacyclouridine (BAU), has been utilized as biochemical modulator of 5‐fluorouracil (5‐FU) anti‐tumor activity in a murine tumor model. The effect of BAU on 5‐FU metabolism has been evaluated using __in vitro__ and __in vivo__ ^19^F NMR spectrosc