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In vivo 19F-NMR of 5-fluorouracil incorporation into RNA and metabolites in Escherichia coli cells

โœ Scribed by Gochin, Miriam; James, Thomas L.; Shafer, Richard H.


Book ID
121913264
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
524 KB
Volume
804
Category
Article
ISSN
0167-4889

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We have used in vivo 19F NMR spectroscopy to study the metabolism of 5-fluorouracil (FUra) in tumors with and without pretreatment with methotrexate (MTX). Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha-fluoro-beta-alanine (F beta ALA), alpha-fluoro-be