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Biological Consequences of Incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-Treated Eukaryotic Cells

โœ Scribed by M. K. Gleason and H. Fraenkel-Conrat


Book ID
123653986
Publisher
National Academy of Sciences
Year
1976
Tongue
English
Weight
684 KB
Volume
73
Category
Article
ISSN
0027-8424

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Background and Objectives: 5-fluorouracil (5-FU) exerts its effects mainly by its incorporation into RNA and inhibition of DNA synthesis. Its toxicity may therefore be estimated by measuring its incorporation into RNA. Protein malnutrition has been considered to increase the toxicity of 5-FU. Method