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In vitro selection of RNA aptamers that block CCL1 chemokine function

✍ Scribed by Martin L. Marro; Dion A. Daniels; David P. Andrew; Trevor D. Chapman; Katy L. Gearing

Book ID
116293499
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
547 KB
Volume
349
Category
Article
ISSN
0006-291X

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin