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In Vitro Selection of RNA Aptamers Directed Against Protein E: AHaemophilus influenzaeAdhesin

✍ Scribed by Barfod, Anders; Singh, Birendra; Johanson, Urban; Riesbeck, Kristian; Kjellbom, Per

Book ID
125377475
Publisher
Humana Press Inc
Year
2014
Tongue
English
Weight
887 KB
Volume
56
Category
Article
ISSN
1073-6085

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin