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In vitro selection of RNA aptamers against a conserved region of thePlasmodium falciparumerythrocyte membrane protein 1

✍ Scribed by Anders Barfod; Tina Persson; Johan Lindh


Book ID
106129589
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
286 KB
Volume
105
Category
Article
ISSN
1432-1955

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An RNA Aptamer That Selectively Inhibits
✍ Brent Townshend; Isabelle Aubry; Richard C. Marcellus; Kalle Gehring; Michel L. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 412 KB πŸ‘ 2 views

## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin