𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In Vitro Selection of the RNA Aptamer against the Sialyl Lewis X and Its Inhibition of the Cell Adhesion

✍ Scribed by Sunjoo Jeong; Tae-Yeon Eom; Se-Jin Kim; Seong-Wook Lee; Jaehoon Yu

Book ID
115587414
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
96 KB
Volume
281
Category
Article
ISSN
0006-291X

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Identification of sialyl Lewis-x in squa
Identification of sialyl Lewis-x in squamous cell carcinoma of the head and neck
✍ R. William Farmer; William J. Richtsmeier; Richard L. Scher πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 197 KB πŸ‘ 2 views

Background. Sialyl Lewis-x (sLx) is a cellular adhesion molecule (CAM) that has been implicated in the inflammatory reaction and cancer metastasis. The sLx is the carbohydrate ligand of endothelial-selectin (E-selectin), an inducible vascular endothelial CAM. The role of sLx has been investigated in

An RNA Aptamer That Selectively Inhibits
An RNA Aptamer That Selectively Inhibits the Enzymatic Activity of Protein Tyrosine Phosphatase 1B in vitro
✍ Brent Townshend; Isabelle Aubry; Richard C. Marcellus; Kalle Gehring; Michel L. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 412 KB πŸ‘ 2 views

## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin