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In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B

โœ Scribed by Khalid Abu Ajaj; Ralph Graeser; Iduna Fichtner; Felix Kratz


Book ID
105993092
Publisher
Springer
Year
2009
Tongue
English
Weight
356 KB
Volume
64
Category
Article
ISSN
0344-5704

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## Abstract The prostateโ€specific antigen (PSA) is a serine protease that is overโ€expressed in prostate carcinoma and represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. We have recently investigated a macromolecular prodrug strategy for improved