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529 POSTER An albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen: development and biological evaluation in an orthotopic mouse model

✍ Scribed by N. Esser; D. Chun; R. Graeser; P. Jantscheff; C. Schaechtele; F. Kratz

Book ID
118624157
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
61 KB
Volume
4
Category
Article
ISSN
1359-6349

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Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP)
✍ Ralph Graeser; Da-Eun Chung; Norbert Esser; Sandra Moor; Christoph Schächtele; C 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 518 KB

## Abstract The prostate‐specific antigen (PSA) is a serine protease that is over‐expressed in prostate carcinoma and represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. We have recently investigated a macromolecular prodrug strategy for improved