Development of a novel prodrug of paclitaxel that is cleaved by prostate-specific antigen: An in vitro and in vivo evaluation study
✍ Scribed by Bakheet Elsadek; Ralph Graeser; Norbert Esser; Cynthia Schäfer-Obodozie; Khalid Abu Ajaj; Clemens Unger; André Warnecke; Tahia Saleem; Nagla El-Melegy; Hafez Madkor; Felix Kratz
- Book ID
- 116430531
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 747 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0959-8049
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## Abstract The prostate‐specific antigen (PSA) is a serine protease that is over‐expressed in prostate carcinoma and represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. We have recently investigated a macromolecular prodrug strategy for improved
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