Bio-Assays for Oxidative Stress Status || IN VIVO TOTAL ANTIOXIDANT CAPACITY: COMPARISON OF DIFFERENT ANALYTICAL METHODS11Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee by the U.S. Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.Address correspondence to: R. L. Prior, Ph.D., USDA, ARS, HNRCA, 711 Washington St., Boston, MA 02111, USA; Tel: (617) 556–3311; Fax: (617) 556-3222; E-Mail: [email protected]. Ronald Prior is a Nutritionist and Laboratory Chief of the Phytochemical Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University, Boston, MA. Dr. Prior received his B.S. degree with honors from the University of Nebraska and he received his Ph.D. in Nutrition and Biochemistry from Cornell University in 1972. Dr. Prior has worked with the USDA for more than 20 years.During the past 12 years at the HNRCA, he has been Scientific Program Officer and has directed research activities dealing with the role of flavonoid and other phenolic food components on antioxidant status, their metabolism, and relationships to diseases of aging.Guohua Cao, M.D., Ph.D., is currently a Scientist II at HNRCA. Dr. Cao studied medicine in Nantong Medical College in 1979 and at Nanjing Medical University in 1984. He obtained his Ph.D. in nutritional biochemistry from Beijing Medical University in 1990. Dr. Cao came to the United States in 1991 and worked at NIH where he was instrumental in developing the ORAC method.
✍ Scribed by PRIOR, RONALD L.
- Book ID
- 126574390
- Publisher
- Elsevier
- Year
- 2001
- Tongue
- English
- Weight
- 986 KB
- Edition
- 1
- Category
- Article
- ISBN
- 0444509577
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✦ Synopsis
This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, Free Radical Biology & Medicine. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal, over many months. This is the first time that all of these expert contributions are presented in one place.
Reliable methods for measuring OSS in organisms are essential. These would, amongst other things, offer applications as early warning signals for cancer and heart disease - eventually giving a range of measurable oxidation products best related to any given disease state.
Additional observations relevant to OSS include: how much do measures of OSS vary in a group of humans? Does OSS decrease as a result of life-change factors and does it increase with age? With disease? With stress? Can a non-invasive, reliable, reputable measure of OSS be identified?
This informative book provides the reader with the latest status of studies into OSS, currently used examples of BOSS, and answers to at least some of the questions posed above.