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Synthesis, Cleavage Profile, and Antitumor Efficacy of an Albumin-Binding Prodrug of Methotrexate that is Cleaved by Plasmin and Cathepsin B

✍ Scribed by André Warnecke; Iduna Fichtner; Gretel Saß; Felix Kratz


Book ID
102751396
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
646 KB
Volume
340
Category
Article
ISSN
0365-6233

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✍ Ralph Graeser; Da-Eun Chung; Norbert Esser; Sandra Moor; Christoph Schächtele; C 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 518 KB

## Abstract The prostate‐specific antigen (PSA) is a serine protease that is over‐expressed in prostate carcinoma and represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. We have recently investigated a macromolecular prodrug strategy for improved