𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vitro and in vivo evaluation of ultrananocrystalline diamond for coating of implantable retinal microchips

✍ Scribed by Xingcheng Xiao; Jian Wang; Chao Liu; John A. Carlisle; Brian Mech; Robert Greenberg; Dilek Guven; Ricardo Freda; Mark S. Humayun; James Weiland; Orlando Auciello

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
471 KB
Volume
77B
Category
Article
ISSN
1552-4973

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this work, ultrananocrystalline diamond (UNCD) thin films were evaluated for use as hermetic and bioinert coatings for a retinal microchip. These films were deposited on highly conductive Si substrates at different temperatures (from 400 to 800Β°C), using microwave plasma enhanced chemical vapor deposition with argon‐rich Ar/CH~4~ gas mixtures and different relative amounts of hydrogen (0–20%). Scanning electron microscopy studies showed that all the films are dense and continuous. Results of cyclic voltammetry test revealed that when there was <2% of hydrogen in the plasma, the film obtained renders the surface electrochemically inactive, with very low leakage currents (∼4 Γ— 10^βˆ’7^ A/cm^2^ at Β±5 V). In addition, in vivo tests of the UNCD‐coated Si samples were performed by implanting them in the eyes of rabbits for 4–6 months within the eye physiological environment. According to all these results, it was concluded that UNCD is a promising candidate for use as the encapsulating coatings for implantable retinal microelectronic devices. Β© 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006

πŸ“œ SIMILAR VOLUMES

In vitro andin vivo mechanical evaluatio
In vitro andin vivo mechanical evaluations of plasma-sprayed hydroxyapatite coatings on titanium implants: The effect of coating characteristics
✍ Yang, C. Y. ;Lin, R. M. ;Wang, B. C. ;Lee, T. M. ;Chang, E. ;Hang, Y. S. ;Chen, πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 646 KB

This study was undertaken to evaluate the effect of coating characteristics on the mechanical strengths of the plasma-sprayed HA-coated Ti-6Al-4V implant system both in vitro and in vivo. Two types of HA coatings (HACs) with quite different microstructures, concentrations of impurityphases, and indi

In vitro and in vivo evaluation of oxyge
In vitro and in vivo evaluation of oxygen effects on a glucose oxidase based implantable glucose sensor
✍ Yanan Zhang; George S. Wilson πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 699 KB

The oxygen effect on a glucose oxidase based implantable glucose sensor was investigated based on studies of tissue oxygen availability and demand for oxygen by the glucose sensor. In vitro measurements showed that the oxygen effect is directly related to the glucose sensor sensitivity and linearity

In vitro and in vivo characterization of
In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors
✍ H. E. Koschwanez; F. Y. Yap; B. Klitzman; W. M. Reichert πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 702 KB

## Abstract The purpose of this study was to test the hypothesis that porous poly‐L‐lactic acid (PLLA) sensor coatings reduce fibrosis and promote blood microvessel formation in tissue adjacent to the sensor surface. Porous PLLA coatings were produced using ammonium bicarbonate as the gas foaming/s

In vitro and in vivo evaluation of contr
In vitro and in vivo evaluation of controlled-release and enteric-coated formulations of sodium salicylate
✍ Lars BorgstrΓΆm; Bo Ekman; Hans Larsson; Ido Leden; Γ…ke Lindahl; Arne Melander; E πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 529 KB

The bioavailability and pharmacokinetics of salicylic acid (SA) were studied after single and multiple doses of a new slow-release formulation, based on porous membrane diffusion of sodium salicylate (NaSA). A solution of NaSA and an enteric-coated tablet of NaSA were used for comparison. Dissolutio

In vitro and in vivo degradation of biom
In vitro and in vivo degradation of biomimetic octacalcium phosphate and carbonate apatite coatings on titanium implants
✍ F. BarrΓ¨re; C. M. van der Valk; R. A. J. Dalmeijer; C. A. van Blitterswijk; K. d πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 442 KB

## Abstract Calcium phosphate (Ca‐P) coatings have been applied onto titanium alloys prosthesis to combine the srength of metals with the bioactivity of Ca‐P. It has been clearly shown in many publications that Ca‐P coating accelerates bone formation around the implant. However, longevity of the Ca