✦ LIBER ✦

In vitro and in vivo evaluation of oxygen effects on a glucose oxidase based implantable glucose sensor

✍ Scribed by Yanan Zhang; George S. Wilson

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 699 KB
Volume: 281
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(93)85009-9

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✦ Synopsis

The oxygen effect on a glucose oxidase based implantable glucose sensor was investigated based on studies of tissue oxygen availability and demand for oxygen by the glucose sensor. In vitro measurements showed that the oxygen effect is directly related to the glucose sensor sensitivity and linearity. Results of in vivo measurements in rat subcutaneous tissue with simultaneously implanted oxygen sensor and glucose sensor also suggested similar influence. A practically useful glucose sensor that is essentially free of oxygen fluctuation can be constructed by controlling its sensitivity and linearity.

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