In silico protein design by combinatorial assembly of protein building blocks
โ Scribed by Hui-Hsu (Gavin) Tsai; Chung-Jung Tsai; Buyong Ma; Ruth Nussinov
- Book ID
- 119824518
- Publisher
- Cold Spring Harbor Laboratory Press
- Year
- 2009
- Tongue
- English
- Weight
- 299 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0961-8368
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
DNA recombination is a powerful engine for the creation of new phenotypes. Recently, methods for in vitro DNA recombination (DNA shuffling) have been developed and applied to the evolution of novel molecules in the laboratory. An exciting new development is the shuffling of homologous genes to creat
Combinatorial libraries in which the individual compounds are connected by dynamic equilibria are able to respond to the environment. If such a system is disturbed by addition of a target molecule (a receptor or a ligand), it will re-equilibrate with the concomitant amplification of compounds which
DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin. The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.