Adaptive Behavior of Dynamic Combinatorial Libraries Generated by Assembly of Different Building Blocks

✍ Scribed by Zacharias Grote; Rosario Scopelliti; Kay Severin

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 150 KB
• Volume: 42
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200351623

✦ Synopsis

Combinatorial libraries in which the individual compounds are connected by dynamic equilibria are able to respond to the environment. If such a system is disturbed by addition of a target molecule (a receptor or a ligand), it will re-equilibrate with the concomitant amplification of compounds which bind to the target molecule. This offers the possibility to utilize dynamic combinatorial libraries (DCLs) for the fast detection of new ligands or new receptors, as demonstrated by several research groups in recent years. [1] Three different types of DCLs obtained by reversible assembly of reactive building blocks can be distinguished (Scheme 1). If only one kind of subunit is employed, structural diversity can be generated by the formation of assemblies with different stoichiometries (Type A). [2] By using two or more structurally diverse building blocks it is possible to obtain libraries with uniform (Type B) or variable stoichiometry (Type C). All three types have been investigated experimentally. [3][4][5] In the following we show that DCLs of Type B and C can display a behavior fundamentally Scheme 1. Different types of dynamic combinatorial libraries obtained by assembly of reactive building blocks.