## Abstract The title compounds were synthesized starting from dimethyl (2S,3aR,8aS)‐(+)‐8‐(phenylsulfonyl)hexahydrophyrrolo[2,3‐b]indole‐1,2‐dicarboxylate. This compound on treatment with LDA followed by reaction with [^14^C]methyl iodide or [^3^H]methyl iodide gave the methyl substituted derivati
Improvement in the synthesis of α-Methyl-L-tryptophan
✍ Scribed by Miguel F. Brana; Mercedes Garrido; Maria L. López; Antonio M. Sanz
- Book ID
- 112126060
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1980
- Tongue
- English
- Weight
- 128 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-152X
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A practical method for the preparation of large amounts of enantiomerically pure alpha-[14C]methyl-L-tryptophan using the enzymatic resolution of the corresponding D,L-methyl ester is reported. The radiolabelled alpha-methyl group was introduced using the alpha-methylation of the lithium enolate of
Local cerebral serotonin synthesis capacity was measured with ␣- [C-11]methyl-L-tryptophan ([C-11]AMT) in normal adult human brain (n ϭ 10; five males, five females; age range, 18-38 years, mean 28.3 years) by using positron emission tomography (PET). [C-11]AMT is an analog of tryptophan, the precur