Enantioselective synthesis of n.c.a. (S)-l-([α-11C]methyl)-tryptophan
✍ Scribed by Alain Plenevaux; Christian Lemaire; Guy Delfiore; Dominique Comar
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 215 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0969-8043
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The title compounds were synthesized starting from dimethyl (2S,3aR,8aS)‐(+)‐8‐(phenylsulfonyl)hexahydrophyrrolo[2,3‐b]indole‐1,2‐dicarboxylate. This compound on treatment with LDA followed by reaction with [^14^C]methyl iodide or [^3^H]methyl iodide gave the methyl substituted derivati
A practical method for the preparation of large amounts of enantiomerically pure alpha-[14C]methyl-L-tryptophan using the enzymatic resolution of the corresponding D,L-methyl ester is reported. The radiolabelled alpha-methyl group was introduced using the alpha-methylation of the lithium enolate of
## Abstract The radiochemical synthesis of N‐[^11^C‐methyl]‐L‐DOPA was accomplished by N‐methylation of the methyl and ethyl esters of L‐N‐tert‐butyl‐oxycarbonyl‐[β‐(3,4‐dimethoxyphenyl)] alaninate with [^11^C]iodomethane using sodium hydride in tetrahydrofuran and deprotection of the N‐methyl inte
Local cerebral serotonin synthesis capacity was measured with ␣- [C-11]methyl-L-tryptophan ([C-11]AMT) in normal adult human brain (n ϭ 10; five males, five females; age range, 18-38 years, mean 28.3 years) by using positron emission tomography (PET). [C-11]AMT is an analog of tryptophan, the precur