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Improved synthesis of the sulfur analog of serotonin (SAS)

✍ Scribed by E. Campaigne; A. Dinner

Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
245 KB
Volume
58
Category
Article
ISSN
0022-3549

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✦ Synopsis

SAS, 3-p-aminoethyl-5-hydroxybenzo(b)thiophene, the sulfur analog of serotonin, has proved refractory to synthesis. The various steps in its preparation have been refined, and its preparation in overall yield of about 20 percent in an eight-step sequence from commercially available m-hydroxyacetophenone has been achieved.

Keyphrases 0 Serotonin, sulfur analog-synthesis 0 3-p-Aminoethyl-5-hydroxybenzo(b)thiophene-improved synthesis 0 NMR spectroscopy-identity, structure 0 IR spectrophotometry-identity, structure 2 Melting ranges were determined with a Mel-Temp apparatus and are corrected. Elemental analyses were obtained from Midwest Microlab, Inc., Indianapolis, Ind. NMR spectra were determined on a Varian HA-100 spectrometer.

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