Improved selectivity in the removal of the tert.-butyloxycarbonyl group
β Scribed by BODANSZKY, MIKLOS ;BODANSZKY, AGNES
- Book ID
- 111860388
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 603 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0367-8377
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π SIMILAR VOLUMES
A disadvantage in the use of the t-butyloxycarbonyl(BOC) groupls2 for N-protection in peptide synthesis is that the acidic conditions normally employed for its removal 3\*495 also effect the cleavage of the t-butyl ester group. The latter is used mainly to
Abstruck Reaction of 3, the N-kc, 0-togrl derivative of phenylalaninol, with base leads to loss of the Boc and tosyl groups and kmnation of oxazdidinone 9. Similar mnctions Jmve also been examined. A medUlismtoeaplainlossoftheBocgn3Upunderbasic reactionEonditionsisprOpoWl.
t-Butyloxycarbonyl (BOC) amino acids are frequently used ae intermediates in peptide synthesis and the reagents normally used for the removal of the protecting group 1,2,3 \_