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Improved selectivity in the removal of the tert.-butyloxycarbonyl group

✍ Scribed by BODANSZKY, MIKLOS ;BODANSZKY, AGNES


Book ID
111860388
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
603 KB
Volume
23
Category
Article
ISSN
0367-8377

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πŸ“œ SIMILAR VOLUMES


Selective cleavage of the t-butyloxycarb
✍ C.J. Gray; A.M. Khoujah πŸ“‚ Article πŸ“… 1969 πŸ› Elsevier Science 🌐 French βš– 209 KB

A disadvantage in the use of the t-butyloxycarbonyl(BOC) groupls2 for N-protection in peptide synthesis is that the acidic conditions normally employed for its removal 3\*495 also effect the cleavage of the t-butyl ester group. The latter is used mainly to

Loss of the tert-butyloxycarbonyl (Boc)
✍ Timothy P. Curran; Michael P. Pollastri; Susan M. Abelleira; Renee J. Messier; T πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 French βš– 298 KB

Abstruck Reaction of 3, the N-kc, 0-togrl derivative of phenylalaninol, with base leads to loss of the Boc and tosyl groups and kmnation of oxazdidinone 9. Similar mnctions Jmve also been examined. A medUlismtoeaplainlossoftheBocgn3Upunderbasic reactionEonditionsisprOpoWl.